Prathista Profile

Dr. Jyoti Khanolkar

Address:

ADI ChemTech
Johnson Square office park,
1513, Johnson Ferry Road,
Suite T12, Marietta,
GA, 30062
United States

Phone: +1 (781) 308-3944

Email: jyotik@adichemtech.com, jyotik@risanpharmachem.com

SUMMARY OF QUALIFICATIONS

Talented, motivated and proactive Pharmaceutical research professional with expertise in organic and medicinal chemistry research. incisive analytical abilities, and strong collaborative skills. Significant areas of contributions and accomplishments include

Organic / Medicinal Chemistry Expertise in new route synthesis (small and large scale), multi-step synthesis, new process development, Scale-up to deliver projects before deadlines and under budget.

Patent Investigation Proven expertise in Patent Search and literature search to design and develop non-infringing routes.

Analytical Chemistry Expertise in various chromatography techniques such as TLC, DSC, KF, GC, IR, LCMS and HPLC method development

Internal Sales Support Proven success working with internal sales team preparing RFP’s, conducting timely follow-ups with existing and potential customers and addressing customer queries to ensure customer satisfaction.

EDUCATION

  • Atlanta Microenterprise initiative, WEDA, GA, USA
  • Ph.D. in Synthetic Organic Chemistry, Institute of Science, Mumbai, India
  • Master of Science in Organic Chemistry, Institute of Science, Mumbai, India

PROFESSIONAL EXPERIENCE

Principal, ADI ChemTech, Marietta, GA (2013-Present)

Visit websitewww.pharma.adichemtech.com and www.adichemtech.com

Senior Scientist, Chemgenes Corporation, Wilmington, MA (2010-2012)

  • Advisory role to various departments such as Research and Development, Quality Control, Sales and Marketing
  • Process development and improvement to increase yield and purity of compounds.
  • Approve Final Products for customer delivery.
  • Design Product Catalogs for new customer acquisition.

Johnson Matthey Pharma, Devens MA (2005 to 2010)

Research Scientist (Organic Chemistry)

Process development for synthesis of biologically active molecules to increase yield and purity of compounds. Carried out small-to-large sized organic synthesis reactions (0.05g to 6kg.) to achieve desired results.

Implemented recovery of trash reverse phase for production and applied cGMP process techniques. Designed a new route for API.

Demonstrated the new route synthesis on 100 g to 6 kg scale as well as on GMP production with optimum purity and yield.

Scientist (Analytical Chemistry)

Developed new HPLC methods for compound detection as per test methods and released the compound for GMP. During this process I handled various instruments such as DSC, KF, GC, IR and LC-MS to produce desired results.

Internal Sales Support associate

Worked with the internal sales team to create proposals and followed up with research team to ensure that contracted services were handled in proficient and professional manner. Diligently followed-up with potential new customers and existing customers to generate sales revenue. Assisted in resolving customer complaints and disputes by gathering information from customers and internal personnel. Maintained consistent communication between various internal groups and external customers acting as a conduit for incoming requests for CDAs, requests for proposals, delivery and shipping information and expediting other customer requests.

Research Organic Chemist, AstraZeneca Pharmaceuticals, Waltham, MA (May 2005 – Nov 2005)

  • Successfully carried out small-to-mid sized organic syntheses (0.1-10 g), as well as small-scale parallel syntheses for discovery or lead-optimization purposes.
  • Carried out Process development to increase yield and purity of compounds.
  • Gathered and organized test data on materials prepared (such as analytical results, biological assay results SAR).
  • Registered new compounds using a number of company databases
  • Regularly communicated results to the group at team meetings.

Senior Research Executive, Kopran Pharmaceuticals, Mumbai, India (2003 – 2004)

  • Carried out total Patent Search for ceftazidine ceftriaxone, azitidine, atorvastatine molecules. (sites USPTO, esp@cenet, STN, Dialog).
  • Carried out Literature search for designing a new route for cefepime.
  • Actively involved in process development and recommended changes in process (by changing solvents, reagents without violating patents) to reduce cost and to improve yield.
  • Handled a team of 4 organic chemists.

Research Scientist, USV Limited, Mumbai India (2002 – 2003)

  • Carried out the synthesis of famciclovir by following patented procedure.
  • Carried out total literature search and patent search and designed a new route for famciclovir. The intermediates and final product were confirmed with 1H NMR, IR, MASS and HPLC.
  • Carried out synthesis of famciclovir using new route with optimum purity and yield. Three successive batches of 100 gms. each obtained with optimum purity.
  • Carried out purification of orlistat.
  • Actively involved in process development for the synthesis of valaciclovir.

PUBLICATIONS

Jyoti M. Shirodkar, and V. V. Mulwad
J. Heterocyclic Chem., 40, 2003, 377.Synthesis anti-fungal and anti-bacterial screening of 3-phenyl-1, 4, 5-trihydro- pyrazol and 2, 4-dihydro [1, 2, 4] triazol-3-one derivatives of 4-hydroxy-2-oxo-2H-1-benzopyran,

Jyoti M. Shirodkar, and V. V. Mulwad
Indian J. Chem., 41B, 2002, 1263. Synthesis of some of the anti-bacterial compounds from 4-Hydroxy coumarins-part-II,

Jyoti M. Shirodkar, and V. V. Mulwad
Indian J. Chem., 42B, 2003, 621-626.Synthesis of biologically active Thiazolo-benzopyranyl–s-triazine derivatives.

Jyoti M. Shirodkar, and V. V. Mulwad
Indian J. Heterocyclic Chem., 11, 2002, 199. Synthesis and biological activity of some new Schiff bases, Thiazolidinones & Azetidinones of 4-Hydroxy coumarin,

Jyoti M. Shirodkar, and V. V. Mulwad
Indian J. Heterocyclic Chem., 11, 2002, 291.Synthesis and biological activity of some new Thiazolidinones & Azetidinones of 6-Amino coumarin,

Jyoti M. Shirodkar, and V. V. Mulwad
Indian J. Heterocyclic Chem., 12, 311-314, 2003.Synthesis of biologically active thieno [3, 2-c] benzopyranyl derivatives,

PRESENTATION / POSTERS

38th annual convention of chemist of 'Indian chemical society'
“Synthesis of biologically active Thiazolo-benzopyranyl–s-triazine derivatives.”

13th conference of 'Indian chemical society'
“Synthesis of biologically active heterocyclic compounds from 4-Hydroxy coumarins”

'Research Scholar Meet-2000'
“Synthesis of biologically active 3-substituted and 3:4 fused heterocyclic compounds from 4-Hydroxy coumarins”

'National Symposium on Frontiers in Organic Chemistry'
“Synthesis and biological activity of some new Schiff bases, Thiazolidinones & Azetidinones of 4-Hydroxy coumarin and amino coumarin,”

SCHOLARSHIPS

A) University MERIT SCHOLARSHIP for Masters Program.

B) State Sponsored Scholarship For Ph.D. program

C) Women’s Graduate Union Prize For Ph.D.

D) LADY TATA MEMORIAL TRUST SCHOLARSHIP– 2000 August-2002 January.

ADDITIONAL QUALIFICATIONS

1) Attended a workshop on “Spectroscopy”

2) Attended a STN Seminar on “Searching Scientific and Patent Information on STN”

3) Attended Dialog Training for Patent Search and literature search